Ostarine (MK-2866)

One of the most popular Selective Androgen Receptor Modulator (SARM)s used by bodybuilders to increase strength and lean muscle mass is ‘Ostarine’. Currently, it is being researched for potential use in reversing muscle breakdown in muscle- wasting diseases. In this article, we have tried to review its potential gains and Uses, coupled with possible side effects and risks.

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What is Ostarine?

Ostarine (MK- 2866), also called enobosarm or Ostabolic, is a Selective Androgen Receptor Modulator (SARM). It stimulates steroid hormone receptors- Androgen receptors- mimicking testosterone.

SARMs differ from typical steroids because of their ability to target specific tissues such as the muscles and bones. This means they have limited side effects. An implication of this is that people who take SARMs don’t have to bother with severe testosterone suppression and increased estrogen.

As a result of their overall gains, SARMs have in recent times surfaced as new popular class of appearance and performance enhancers.

A whole lot of athletes and bodybuilders speak favorably of Ostarine and claims it offers significant performance gains and muscle mass with few risks.

Going by its action mechanism, Ostarine ought to be safer than other steroids. Although it has greater safety levels compared to other SARMs, it has not yet been approved for human use in any part of the world.

Ostarine and other SARMs are currently being researched for their ability to improve severe muscle wasting diseases. In fact, Ostarine was initially developed to totally prevent complete muscle loss and target muscle wasting diseases.

An interesting fact to note is that Ostarine is one of the few SARMs still in Clinical trials (by GTx), while the majority of others proved to be too toxic.

Ostarine may be approved for future clinical use if the ongoing trial tests can favorably attest a benefit/risk ratio. However, it is almost certain that it’s use in professional sport will remain illegal. The current standing of things show that Ostarine was banned by the World Anti- Doping Agency under the S1 Anabolic Agent Category of the prohibited list, along with all other SARMs far back in 2008.

Potential Uses Of Ostarine

Ostarine MK 2866 results before and after

Bone Health

Poor bone health and osteoporosis is usually caused by a decrease in bone- protective sex hormone with age. Though enhancing bone mineralization is important, increasing muscle mass can drastically reduce the risk of bone fracture and speed up recovery. The whole skeletal system is supported by muscles and their strength and good health help in healing fractures, especially in older people.

Since Ostarine mimics testosterone in the bones and muscles, it has the potential of preventing bone diseases. Studies from Animals have shown that SARMs like Ostarine could increase both bone strength and muscles. No human study has confirmed this benefit however.

Improvements were mainly seen in structural properties such as bone mineral density and bone volume density.

Evaluation of ostarine as a selective androgen receptor modulator in a rat model of postmenopausal osteoporosis.

Muscle Mass

Ostarine is currently being researched for the reversal of muscle loss in  people with muscular dystrophy, the aging population and cancer patients.

During a clinical trial of 120 healthy elderly people  (double- blind randomized controlled trial), enobosarm increased fitness and lean muscle mass. However, only those who received 3 mg of enobosarm daily for 12 weeks saw benefits. The lower doses didn’t work quite as well. Interestingly, it’s side effects were very similar to placebo due to it’s lack of steroid- like risks.

In a separate trial, enobosarm was able to safely increase lean muscle mass in 159 cancer patients. Most cancer patients who were already losing muscle mass rapidly prior to the study, gained about 2-3 Ibs after taking enobosarm for a duration of about 4 months. The higher  (3mg/day) and lower (1mg/day) doses worked equally well.

Importantly, this study provides evidence that GTx-024 provides beneficial anabolic effects on total lean body mass and physical function without the adverse consequences often seen with testosterone and other anabolic steroids.

Male osteoporosis and androgenic therapy: from testosterone to SARMs

Large scale clinical trials of enobosarm for preventing muscle loss in cancer patients are currently underway.

In rodents such as rats, oral enobosarm was completely absorbed. Hence, it is assumed that it could be widely distributed around the body and eliminated through detox pathways.

Insulin Resistance

In the above- mentioned study of 120 healthy elderly people, enobosarm was seen to have improved insulin resistance and drastically powered blood glucose. Moreover, it bore somewhat similar effects to standard anti- diabetic drugs such as metformin. Therefore, Ostarine may just be able to benefit people with diabetes or metabolic syndrome.

Heart Health

Another area where Ostarine might prove beneficial is to people who often suffer from muscle wasting and weight loss due to heart disease.

In the same clinical trial of 120 healthy elderly people, enobosarm (1-3mg/day) lowered lipids in the blood such as total cholesterol, HD cholesterol and triglycerides.

When the lipids levels are healthy, it counters against heart disease. However, the lowering of HDL is not considered to be beneficial.

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Dosage In Clinical Studies

It was discovered during the clinical studies that 1mg/day dose of Ostarine increased total lean body mass by over 3 pounds.

On the other hand, the 3mg/day dose of Ostarine increased total lean body mass by only 2 pounds after almost 3 months in cancer patients.

Elderly people gained muscle mass only when using the 3mg/per dosage.

PROS:

  • It shouldn’t cause hormonal imbalance
  • Increases lean muscle mass and strength
  • It may improve insulin resistance and lower cholesterol
  • Only mild side effects have been reported
  • May improve bone strength

CONS:

  • It is not yet allowed for use in professional sport
  • Long term risks are unknown
  • It has not yet been approved for human consumption in any country

Side Effects Of Ostarine

The list below comprises side effects that users of Ostarine have experienced during usage. They include;

  • Decreased sense of wellness after first 9 days.
  • Testicle pain
  • No increase in strength or muscle size after 5 weeks
  • Reduces strength
  • Joint pains
  • Erection difficulties
  • Disrupted sleep
  • Depression
  • Low energy
  • Menstrual cycle imbalances
  • Headaches
  • Baldness
  • Acne and skin changes.
Side Effects of Ostarine (MK-2866)

Users Review of Ostarine

We have tried our best to categorize all the reviews so you can consider that which pertains to you the most.

The reviews below are all based on users’ reports.

Bulking Cycles

  • Milder gains than with steroids.
  • Pure clean dry muscle gains.
  • Increased protein synthesis
  • No water retention
  • Increased lifting endurance, strength and stamina
  • Great pumps during workout
  • No post- cycle crashes
  • No need for liver support supplements
  • No increase in aggression.

Body Recomposition

When using Ostarine for re- comping, users reported that;

  • Gaining muscles
  • Gaining some weight overall
  • Losing fat

Muscle Recovery

  • Enhance muscle recovery
  • Effects noticeable after a week or two
  • Better joint mobility
  • Healing of bone and tendon injuries
  • Improved injury prevention.

Cutting and Fat Burning

  • No strength loss
  • Maintaining muscle mass
  • Loss of fat
Ostarine Reviews
  • Pure Lean Mass Gains
  • Cutting & Fatloss
  • Muscle and Joints Recovery
  • Bone Health
4.8

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